Tough on the tumor. Easier on you and your caregivers.
The first radiation treatment specifically designed for use inside the brain, GammaTile Therapy gives patients a head STaRT and new hope in the fight against recurrent brain tumors. It also eliminates the need for traditional treatments and associated hospital or clinic visits, so patients can focus on what matters most—healing.
The neurosurgeon places GammaTile(s) precisely where and when treatment will help the most—immediately after tumor removal.
Radiation is focused right where it is needed and away from healthy brain tissue.
Most patients experience fewer side effects compared to patients who receive other, more-traditional repeat-radiation treatments.[1–3]
There is no need for an extra hospital stay or to travel for additional, ongoing radiation treatments.
Find a GammaTile Therapy Center near you.
Arizona PBS | June 11, 2019 | Implantable brain tumor treatment GammaTile Therapy with Dr. David Brachman.
Minnesota CBS | February 14, 2019 | New brain cancer treatment GammaTile Therapy at University of Minnesota with survivor Linda Tinega.
Arizona CBS | August 14, 2019 | New therapy to slow down brain tumors forever changes Arizona woman's life.
North Carolina WNCT | January 22, 2020 | Vidant, ECU Brody School of Medicine successfully perform first-in-state GammaTile procedure.
Cronkite News Division of Arizona PBS | Oct 22, 2019 | Battling brain tumors with time-released radiation
Patient Testimonial Video | Joan, A survivor treated with GammaTile Therapy
Physician Testimonial Video | Dr. Clark Chen, University of Minnesota
Patient Testimonial Video | Oscar, High-grade glioma survivor
GammaTile Therapy Videos
Learn more about GammaTile Therapy and hear from patients about their treatment experience.
Ohio CBS | August 20, 2019 | Mayfield brain and spine neurosurgeon using new radiation therapy.
“My quality of life has been very good due to the good results I’ve had with GammaTile Therapy. I’m just really thankful that GammaTile Therapy was available because otherwise, I would have had to have another brain surgery.”
Joan | The first patient in Arizona to receive GammaTile Therapy. Watch Joan's video.
GammaTile Therapy Webinar
Watch an in-depth educational webinar about GammaTile Therapy, presented by world-renowned neurosurgeon Dr Joseph Zabramski and hosted by The Musella Foundation. Content includes background, safety and efficacy, surgical placement, a case study, and clinical trial information. Watch the GammaTile Therapy Webinar
Frequently asked questions
What is GammaTile Therapy?
GammaTile is a Surgically Targeted Radiation Therapy (STaRT) for brain tumors that provides immediate radiation treatment after tumor removal. Each GammaTile has radiation sources embedded in a collagen tile that deliver a precise dose of radiation focused right where it’s needed and away from healthy brain tissue. In a clinical study, this resulted in a 2x improvement in median time to tumor recurrence compared to the patients’ most recent prior same site treatment.
How does GammaTile Therapy work?
The neurosurgeon places the GammaTile(s) precisely where treatment will help the most—immediately after tumor removal. Like other radiation therapies, GammaTile Therapy works by disrupting the tumor cell replication process. Radiation damages the tumor cell DNA, so the cell is unable to replicate and eventually dies. The collagen tile keeps the radiation sources in place while the radiation is being released. Over time, the body naturally absorbs the collagen tile.
Is GammaTile FDA approved?
GammaTile Therapy is FDA cleared to deliver radiation therapy for patients with newly diagnosed malignant brain tumors and recurrent brain tumors.
How is GammaTile Therapy different from other types of radiation therapy used to treat brain tumors?
The two most common types of radiation therapy used to treat brain tumors are external beam radiation therapy (EBRT) and brachytherapy.
With EBRT, the radiation comes from a machine outside the body into the tumor area. One of the drawbacks of EBRT is that patients have to wait 2 to 3 weeks before beginning the radiation therapy to allow the surgical incision to heal after tumor removal surgery due to the potential of the radiation interfering with wound healing. Unfortunately, this treatment lapse provides a window for any remaining tumor cells to duplicate and grow. In addition, EBRT requires an intense treatment schedule (typically 15-30 sessions, 5 days a week for 3 to 6 weeks) at a hospital or treatment center.
With brachytherapy, or internal radiation therapy, radiation sources are placed within the tumor resection cavity during surgery. While the radiation begins working right away, the dose can be extremely high around the radiation source. This can cause serious side effects, including swelling and damage to healthy brain tissue.
GammaTile Therapy starts targeting any remaining tumor cells immediately upon placement. And with GammaTile Therapy, there’s no intense treatment schedule or need for patients and their caregivers to travel to and from a treatment center. Patients receive treatment in the comfort of their own homes, going about their daily life.
GammaTile Therapy is different from traditional brachytherapy because the collagen tile provides a buffer around the radiation sources which allows the patient to receive the optimal dose of radiation to tumor cells while preserving healthy tissue and minimizing complications.
GammaTile Therapy gives patients get a head start in the fight against brain tumor regrowth while reducing the potential for side effects.
Do I have to stay in the hospital longer if I receive GammaTile Therapy?
No, typically there is no need for an extra hospital stay or to travel for additional, ongoing radiation treatments.
Will GammaTile Therapy lengthen my surgery?
No, GammaTile Therapy placement only takes a few minutes at the end of surgery.
Does GammaTile Therapy replace chemotherapy?
Your treatment team may use GammaTile Therapy in conjunction with chemotherapy, depending on the type of tumor. Talk with your treatment team for guidance about your individual care plan.
If I have had radiation therapy in the brain previously, can I still have GammaTile Therapy?
In a recent clinical study, all patients treated with GammaTile Therapy had previous radiation therapy in the brain. However every situation is unique. Together with your care team, your radiation oncologist will review your previous records to determine if GammaTile Therapy might be right for you.
How long is the GammaTile radioactive?
With GammaTile Therapy, 90% of the radiation dose is delivered in 33 days. After 100 days, the GammaTile radiation sources are considered completely free of radiation.
Can a patient have GammaTile Therapy more than once?
Yes, it is possible to receive GammaTile Therapy more than once if you meet the medical criteria and you and your healthcare provider decide it is appropriate for you.
Will I need to have surgery to remove GammaTile?
No, one of the great things about GammaTile Therapy is that the body naturally absorbs the collagen tile and the small, inactive seeds remain in the body.
Can GammaTile Therapy be used for cancers outside of the brain?
Currently, GammaTile Therapy is only indicated for brain tumor treatment.
What are the side effects of GammaTile Therapy?
Compared to other radiation treatments, GammaTile Therapy side effects are typically fewer. The potential for adverse events depends on the radiosensitivity of the exposed tissue, the amount of radiation delivered, and the placement of GammaTile(s).
Because GammaTile is placed during tumor removal surgery, the possible complications of neurosurgery may also apply, including, but not limited to, cerebrospinal fluid leaks, infection, delayed hemorrhage, seizures, and adhesion formation. For more information about potential side effects, talk to your healthcare provider.
Will GammaTile Therapy cause hair loss?
With GammaTile Therapy, radiation does not have to travel from outside the body through the scalp to reach the tumor cells. Therefore, the likelihood of hair loss is low. In a clinical study on GammaTile Therapy, only 1 out of 74 patients experienced hair loss.
Below are the answers to important questions about GammaTile Therapy for people with brain tumors and their caregivers. Please speak with your treatment team to see if GammaTile Therapy is right for you or your loved one.
1. Nakaji P, Youssef E, Dardis C, Smith K, Pinnaduwage D, Brachman D. Surgically targeted radiation therapy: a prospective trial in 79 recurrent, previously irradiated intracranial neoplasms. Poster
presented at: 2019 AANS Annual Scientific Meeting; April 2019; San Diego, CA.
2. Combs SE, Debus J, Schulz- Ertner D. Radiotheraputic alternatives for previously irradiated recurrent gliomas. BMC Cancer. 2007;7:167.
3. Wernicke AG, Smith AW, Taube S, et al. Cesium-131 brachytherapy for recurrent brain metastases: durable salvage treatment for previously irradiated metastatic disease. J Neurosurg.
4. Magill ST, Lau D, Raleigh DR, Sneed PK, Fogh SE, McDermott MW. Surgical resection and interstitial iodine-125 brachytherapy for high-grade meningiomas: a 25-year series. Neurosurgery.
5. Armpilia CI,Dale RG, Coles IP,Jones B,Antipas V. The determination of radiobiologically optimized half-lives for radionuclides used in permanent brachytherapy implants. Int J Radiat Oncol Bio Phys.
GammaTile Therapy is indicated to deliver radiation therapy for patients with newly diagnosed malignant intracranial neoplasms and recurrent intracranial neoplasms. For full safety information, refer to the instructions for use.